Diseases Treated

How can cord blood help?

Research continues to reveal new potential medical benefits from using cord blood stem cells. Today, they may be used in the treatment of over 75 life-threatening diseases. These include a wide range of cancers, genetic diseases, immune deficiencies, and blood disorders.1 In fact, cord blood stem cells have been used in more than 20,000 transplants worldwide.2

Below are examples of diseases that have been treated with cord blood stem cells:

Acute Leukemia:

  • Acute Lymphoblastic Leukemia(ALL)
  • Acute Myelogenous Leukemia(AML)
  • Acute Biphenotypic Leukemia
  • Acute Undifferentiated Leukemia

Chronic Leukemia:

  • Chronic Myelogenous Leukemia(CML)
  • Chronic Lymphocytic Leukemia(CLL)
  • Juvenile Chronic Myelogenous Leukemia(JCML)
  • Juvenile Myelomonocytic Leukemia(JMML)

Histiocytic Disorders:

  • Familial Erythrophagocytic
    Lymphohistiocytosis
  • Histiocytosis-X
  • Hemophagocytosis

Inherited Metabolic Disorders:

  • Mucopolysaccharidoses(MPS)
  • Hurler's Syndrome(MPS-IH)
  • Sanfilippo Syndrome(MPS-III)
  • Maroteaux-Lamy Syndrome (MPS-VI)
  • Adrenoleukodystrophy
  • Krabbe Disease
  • Niemann-Pick Disease
  • Metachromatic Leukodystrophy
  • Scheie Syndrome(MPS-IS)
  • Hunter's Syndrome(MPS-II)
  • Morquio Syndrome(MPS-IV)
  • Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
  • Mucolipidosis II (I-cell Disease)
  • Gaucher's Disease
  • Wolman Disease

Inherited Erythrocyte Abnormalities

  • Beta Thalassemia Major
  • Sickle Cell Disease

Inherited Immune System Disorders

  • Ataxia-Telangiectasia
  • Kostmann Syndrome
  • Leukocyte Adhesion Deficiency
  • DiGeorge Syndrome
  • Bare Lymphocyte Syndrome
  • Omenn's Syndrome
  • Severe Combined Immunodeficiency (SCID)
  • SCID with Adenosine Deaminase Deficiency
  • Absence of T & B Cells SCID
  • Absence of T Cells, Normal B Cell SCID
  • Common Variable Immunodeficiency
  • Wiskott-Aldrich Syndrome
  • X-Linked Lymphoproliferative Disorder

Inherited Platelet Abnormalities

  • Amegakaryocytosis / Congenital Thrombocytopenia
 

Other Inherited Disorders

  • Osteoporosis
  • Lesch-Nyhan Syndrome
  • Cartilage-Hair Hypoplasia
  • Glanzmann Thrombasthenia

Lymphoproliferative Disorders:

  • Non-Hodgkin's Lymphoma
  • Hodgkin's Disease

Myelodysplastic Syndromes:

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia (myelofibrosis)
  • Polycythemia Vera
  • Essential Thrombocythemia

Phagocyte Disorders:

  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Neutrophil Actin Deficiency
  • Reticular Dysgenesis

 

Plasma Cell Disorders

  • Multiple Myeloma
  • Plasma Cell Leukemia
  • Waldenstrom's Macroglobulinemia

Other Malignancies - Rescue After Bone Marrow Transplant Failure

  • Breast Cancer
  • Wing Sarcoma
  • Neuroblastoma
  • Renal Cell Carcinoma
  • Retinoblastoma

REF:

  1. Moise EA and Kenneth J. Umbilical Cord Stem Cells. Obstetrics & Gynecology 2005;106:1393-1407.
  2. Rocha V and Gluckman E. Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors. Br J of Haematol 2009;147:262–274.